Neurology Central

Targeting cerebrovascular impairments in Huntington’s disease: a novel treatment perspective

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It is increasingly recognized that, in addition to blatant neuronal cell loss and the prominent expression of abnormal misfolded proteins, neurodegenerative disorders of the CNS are associated with significant alterations of the cerebral vasculature, in particular impairments of the neurovascular unit and increased permeability of the blood–brain barrier (BBB). Changes in brain-associated vascular networks are well characterized in Alzheimer’s disease (AD) and in normal aging [1]. However, they have received less attention in the context of other neurodegenerative conditions such as Huntington’s diseases (HD), despite the fact that the very first evidence of cerebrovascular-associated irregularities in individuals affected with HD – which highlighted degeneration of blood vessels, thickening and inflammation of the leptomeninges as well as more frequent subdural hemorrhages in this patient population – were published in the late 1800s (see review [2]).

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